WCA2026 Webinars

Moderators:

• Pui-San Loh (Malaysia)
• Vivian Ip (Canada)
• Jodi Sherman (USA)

Speakers:

• Seema Gandhi (India)
• Clifford Shelton (United Kingdom)
• Gwen Morgan (South Africa)

Learning Objectives

• Talk 1: N2O climate impacts, policy and practice – Clifford L Shelton
  
  This talk provides the foundation to:

1. Understand the environmental impacts of N2O.
2. Recognise the major sources of N2O waste and emissions.
3. Consider strategies to mitigate N2O-related emissions while maintaining excellent standards of patient care.

• Talk 2: Implementation challenges and opportunities from the perspective of high-income countries – Seema Gandhi 

At the end of the session, attendees should be able to:

1. Obtain the data required to calculate the discrepancy between clinical delivery and procurement to estimate nitrous oxide losses.
2. Identify the key team members in forming a multidisciplinary team and define the roles & responsibilities of each member.
3. Understand a step-by-step process of transition to a portable delivery system based on case studies from multiple health systems.

• Talk 3: Implementation challenges and opportunities from the perspective of low-income countries – Gwen Morgan
  
  This lecture aims to give the audience the following learning opportunities:

1. The importance of action in LMIC:
   • Environmental degradation and climate change are projected to affect these countries disproportionately.
   • Efficiency in resource-constrained settings.
   • Importance of avoiding fruitless expenditure.

2. Knowledge gaps:
   • Reliance upon N2O in LMIC.
   • Availability of alternatives.
   • Practice norms in LMIC.
   • N2O costs in LMIC.
   • Practicalities of adopting POC cylinders (anaesthetic machine compatibility, local regulations, local availability of E-cylinders, cost implications of smaller cylinder sizes, road transport of N2O).

Chair:

• Norifumi Kuratani (Japan)

Co-Chair:

• Zehra Serpil Ustalar Özgen (Türkiye)

Speakers:

• Jin-Tae Kim (Korea)
• Mehdi Trifa (Tunisia)

Learning Objectives

Topic 1 : Global issues in the care of paediatric cardiac patients:

• Explore Global Disparities in Paediatric Cardiac Care: Attendees will gain an understanding of the global challenges in providing access to paediatric cardiac care in low-resource settings and the implications for patient outcomes.
• Implement Innovative and Collaborative Solutions for Paediatric Cardiac Anaesthesia Programmes: Attendees will learn about innovative approaches, including telemedicine, surgical missions, capacity-building programmes, and echocardiography education aimed at improving care for paediatric cardiac patients with limited resources.

Topic 2 : Anaesthesia of the child with left-to-right shunt for non-cardiac surgery:

• Analyse the haemodynamic considerations in paediatric patients with left-to-right shunts.
• Develop a comprehensive perioperative management plan to minimise risks for paediatric patients with left-to-right shunts undergoing non-cardiac surgery.
  Illustrate clinical management strategies for paediatric patients with left-to-right shunts through a detailed case study example.

Moderators:

• Nabil Elkassabany (USA)
• Kariem Elboghdadly (UK)

Speakers:

• Justin Ko (Korea)
• Mohamed Mohamed (Egypt)
• Ana Schwartzman (Uruguay)

Learning Objectives

Topic 1 : Ultrasound-guided spinal anaesthesia :

• Understand the benefits of ultrasound guidance in spinal anaesthesia, including higher first-attempt success rates and fewer needle passes.
• Differentiate between pre-procedural ultrasound scans and real-time ultrasound guidance.
• Recognise challenges in adopting ultrasound-guided techniques in clinical practice and resident training.
• Explore how ultrasound enhances patient comfort and procedural efficiency during spinal anaesthesia.

Topic 2 : Perioperative care for hip fracture

• Standards of perioperative care for hip fracture.
• Understanding the controversies among anaesthetists in managing patients with hip fractures worldwide.
• REGAIN trial: know more about the study design, strengths, and limitations.

Topic 3 : Fascial plane blocks in renal transplant surgery

• Discuss the role and benefits of fascial plane blocks in providing effective analgesia for renal transplant surgery.

Moderators:

• Carin Hagberg – USA
• Daniel Perin – Brazil
• Abderrahmane Boaggad – Morocco

Speakers:

• Anil Patel – United Kingdom
• Sheila Myatra – India
• Ellen O’Sullivan – Ireland

Learning objectives

• 1) Role of HFNO in the obstructed airway – Anil Patel (UK)
  The obstructed airway can lead to life-threatening airway compromise, requiring urgent intervention. The goal of this talk is to understand the physiological principles and role of HFNO in the management of the obstructed airway. These include (i) improvements in oxygenation, (ii) improved CO2 clearance with enhanced washout of anatomical dead space, (iii) generation of positive pressure opening the airway, (iv) reduced work of breathing, and (v) reduced patient distress.
• 2) “The tube went in, but my patient still collapsed”
  The physiologically difficult airway: preventing cardiovascular collapse  – Sheila Myatra (India)
  Complications associated with tracheal intubation in critically ill patients remain high, with hypotension being the most common. The goal of this talk is to understand the challenges associated with emergent tracheal intubation in critically ill patients who often present with a physiologically difficult airway and discuss optimisation strategies as well as controversies in this arena.
• 3) Management of Post Thyroidectomy Bleed: Dos and Don’ts – Ellen O’Sullivan (Ireland)
  Thyroid surgery is common, with bleeding a complication requiring re-operation in over 1.3% of all cases. This presentation will focus on the observations required to avoid missing a neck haematoma, the need for, and contents of, a post-thyroid surgery emergency box near the bedside, and how best to manage this life-threatening complication.

Chair:

• Adnane Berdai – Morocco, Co-Chair Obstetric Anaesthesia Track

Speakers:

• Cynthia Wong – USA, Obstetric Anaesthesia Track Member
• Nuala Lucas – UK, Obstetric Anaesthesia Track Member

Learning objectives

• Current role of general anaesthesia for caesarean delivery: Describe indication, predisposing factors, anaesthetic outcome and identify the main maternal and foetal risks associated with general anaesthesia.
• Airway management in caesarean delivery: Describe mode of airway management including choice of airway devices and intubation technique. Detail recognition and management of the difficult airway, and describe an algorithmic approach. Specify the risks of aspiration and upper airway obstruction at extubation in caesarean delivery.
• Technique of general anaesthesia for caesarean delivery: Detail the anaesthetic induction, taking into account obstetric and foetal considerations. Describe maintenance of anaesthesia while minimising the risk of intraoperative awareness and avoiding uterine atony. Plan a multimodal postoperative analgesia technique.

Chair:

• Daniela Filipescu – Romania, Co-chair WCA2026

Speakers

• Elie Azoulay – France, Co-chair WCA2026 Critical Care Track
• Samir Jaber – France, Co-chair WCA2026 Scientific Committee

Learning objectives

• Review of Recent Publications: Understand and analyse selected recent publications in intensive care, acute respiratory failure, anaesthesia care, and perioperative medicine that could impact clinical practices.
• Focus on Randomised Controlled Trials (RCTs): Explore new findings from major RCTs that have implications for clinical decision-making and practice.
• Integration of Knowledge: Gain an integrated overview from the operating room to the intensive care unit, emphasizing topics such as respiratory management, hemodynamics, care of immunocompromised patients, and organ support.

Resources

Samir Jaber

1. De Jong A, Molinari N, Pouzeratte Y, Verzilli D, Chanques G, Jung B, Futier E, Perrigault PF, Colson P, Capdevila X, Jaber S. Difficult intubation in obese patients: incidence, risk factors, and complications in the operating theatre and in intensive care units. Br J Anaesth. 2015 Feb;114(2):297-306.

doi: 10.1093/bja/aeu373. Epub 2014 Nov 27. PMID: 25431308.

https://pubmed.ncbi.nlm.nih.gov/25431308

• Vourc’h M, Huard D, Le Penndu M, Deransy R, Surbled M, Malidin M, Mahe PJ, Guitton C, Roquilly A, Malard O, Feuillet F, Rozec B, Asehnoune K. High-flow oxygen therapy versus facemask preoxygenation in anticipated difficult airway management (PREOPTI-DAM): an open-label, single-centre, randomised controlled phase 3 trial. EClinicalMedicine. 2023 May 22;60:101998.

doi: 10.1016/j.eclinm.2023.101998. PMID: 37251624; PMCID: PMC10220226.

https://pubmed.ncbi.nlm.nih.gov/37251624

• Schutzer-Weissmann J, Wojcikiewicz T, Karmali A, Lukosiute A, Sun R, Kanji R, Ahmed AR, Purkayastha S, Brett SJ, Cousins J. Apnoeic oxygenation in morbid obesity: a randomised controlled trial comparing facemask and high-flow nasal oxygen delivery. Br J Anaesth. 2023 Jan;130(1):103-110. 

DOI: 10.1016/j.bja.2021.12.011

https://pubmed.ncbi.nlm.nih.gov/35027169

• Vourc’h M, Baud G, Feuillet F, Blanchard C, Mirallie E, Guitton C, Jaber S, Asehnoune K. High-flow Nasal Cannulae Versus Non-invasive Ventilation for Preoxygenation of Obese Patients: The PREOPTIPOP Randomized Trial. EClinicalMedicine. 2019 Jun 5;13:112-119.

doi: 10.1016/j.eclinm.2019.05.014. PMID: 31528849; PMCID: PMC6737343.

https://pubmed.ncbi.nlm.nih.gov/31528849

• Baillard C, Fosse JP, Sebbane M, Chanques G, Vincent F, Courouble P, Cohen Y, Eledjam JJ, Adnet F, Jaber S. Noninvasive ventilation improves preoxygenation before intubation of hypoxic patients. Am J Respir Crit Care Med. 2006 Jul 15;174(2):171-7.

doi: 10.1164/rccm.200509-1507OC. Epub 2006 Apr 20. PMID: 16627862.

https://pubmed.ncbi.nlm.nih.gov/16627862

• Gibbs KW, Semler MW, Driver BE, Seitz KP, Stempek SB, Taylor C, Resnick-Ault D, White HD, Gandotra S, Doerschug KC, Mohamed A, Prekker ME, Khan A, Gaillard JP, Andrea L, Aggarwal NR, Brainard JC, Barnett LH, Halliday SJ, Blinder V, Dagan A, Whitson MR, Schauer SG, Walker JE Jr, Barker AB, Palakshappa JA, Muhs A, Wozniak JM, Kramer PJ, Withers C, Ghamande SA, Russell DW, Schwartz A, Moskowitz A, Hansen SJ, Allada G, Goranson JK, Fein DG, Sottile PD, Kelly N, Alwood SM, Long MT, Malhotra R, Shapiro NI, Page DB, Long BJ, Thomas CB, Trent SA, Janz DR, Rice TW, Self WH, Bebarta VS, Lloyd BD, Rhoads J, Womack K, Imhoff B, Ginde AA, Casey JD; PREOXI Investigators and the Pragmatic Critical Care Research Group. Noninvasive Ventilation for Preoxygenation during Emergency Intubation. N Engl J Med. 2024 Jun 20;390(23):2165-2177.

doi: 10.1056/NEJMoa2313680. Epub 2024 Jun 13. PMID: 38869091; PMCID: PMC11282951. https://pubmed.ncbi.nlm.nih.gov/38869091/

• Detsky ME, Jivraj N, Adhikari NK, et al. Will This Patient Be Difficult to Intubate? The Rational Clinical Examination Systematic Review. JAMA. 2019;321(5):493–503.

doi:10.1001/jama.2018.21413

https://jamanetwork.com/journals/jama/article-abstract/2724031

• De Jong A, Molinari N, Terzi N, Mongardon N, Arnal JM, Guitton C, Allaouchiche B, Paugam-Burtz C, Constantin JM, Lefrant JY, Leone M, Papazian L, Asehnoune K, Maziers N, Azoulay E, Pradel G, Jung B, Jaber S; AzuRéa Network for the Frida-Réa Study Group. Early identification of patients at risk for difficult intubation in the intensive care unit: development and validation of the MACOCHA score in a multicenter cohort study. Am J Respir Crit Care Med. 2013 Apr 15;187(8):832-9.

doi: 10.1164/rccm.201210-1851OC. PMID: 23348979.

https://pubmed.ncbi.nlm.nih.gov/23348979

• Russotto V, Lascarrou JB, Tassistro E, Parotto M, Antolini L, Bauer P, Szułdrzyński K, Camporota L, Putensen C, Pelosi P, Sorbello M, Higgs A, Greif R, Grasselli G, Valsecchi MG, Fumagalli R, Foti G, Caironi P, Bellani G, Laffey JG, Myatra SN; INTUBE Study Investigators. Efficacy and adverse events profile of videolaryngoscopy in critically ill patients: subanalysis of the INTUBE study. Br J Anaesth. 2023 Sep;131(3):607-616.

doi: 10.1016/j.bja.2023.04.022. Epub 2023 May 17. PMID: 37208282.

https://pubmed.ncbi.nlm.nih.gov/37208282

1. Prekker ME, Driver BE, Trent SA, Resnick-Ault D, Seitz KP, Russell DW, Gaillard JP, Latimer AJ, Ghamande SA, Gibbs KW, Vonderhaar DJ, Whitson MR, Barnes CR, Walco JP, Douglas IS, Krishnamoorthy V, Dagan A, Bastman JJ, Lloyd BD, Gandotra S, Goranson JK, Mitchell SH, White HD, Palakshappa JA, Espinera A, Page DB, Joffe A, Hansen SJ, Hughes CG, George T, Herbert JT, Shapiro NI, Schauer SG, Long BJ, Imhoff B, Wang L, Rhoads JP, Womack KN, Janz DR, Self WH, Rice TW, Ginde AA, Casey JD, Semler MW; DEVICE Investigators and the Pragmatic Critical Care Research Group. Video versus Direct Laryngoscopy for Tracheal Intubation of Critically Ill Adults. N Engl J Med. 2023 Aug 3;389(5):418-429.

doi: 10.1056/NEJMoa2301601. Epub 2023 Jun 16. PMID: 37326325; PMCID: PMC11075576.

https://pubmed.ncbi.nlm.nih.gov/37326325

1. Cortellazzi P, Caldiroli D, Byrne A, Sommariva A, Orena EF, Tramacere I. Defining and developing expertise in tracheal intubation using a GlideScope(®) for anaesthetists with expertise in Macintosh direct laryngoscopy: an in-vivo longitudinal study. Anaesthesia. 2015 Mar;70(3):290-5.

doi: 10.1111/anae.12878. Epub 2014 Oct 1. PMID: 25271442.

https://pubmed.ncbi.nlm.nih.gov/25271442

1. Amalric M, Larcher R, Brunot V, Garnier F, De Jong A, Moulaire Rigollet V, Corne P, Klouche K, Jung B. Impact of Videolaryngoscopy Expertise on First-Attempt Intubation Success in Critically Ill Patients. Crit Care Med. 2020 Oct;48(10):e889-e896.

doi: 10.1097/CCM.0000000000004497. PMID: 32769622.

https://pubmed.ncbi.nlm.nih.gov/32769622

1. Futier E, Constantin JM, Paugam-Burtz C, Pascal J, Eurin M, Neuschwander A, Marret E, Beaussier M, Gutton C, Lefrant JY, Allaouchiche B, Verzilli D, Leone M, De Jong A, Bazin JE, Pereira B, Jaber S; IMPROVE Study Group. A trial of intraoperative low-tidal-volume ventilation in abdominal surgery. N Engl J Med. 2013 Aug 1;369(5):428-37.

doi: 10.1056/NEJMoa1301082. PMID: 23902482.

https://pubmed.ncbi.nlm.nih.gov/23902482

1. Ferrando C, Carramiñana A, Piñeiro P, Mirabella L, Spadaro S, Librero J, Ramasco F, Scaramuzzo G, Cervantes O, Garutti I, Parera A, Argilaga M, Herranz G, Unzueta C, Vives M, Regi K, Costa-Reverte M, Sonsoles Leal M, Nieves-Alonso J, García E, Rodríguez-Pérez A, Fariña R, Cabrera S, Guerra E, Gallego-Ligorit L, Herrero-Izquierdo A, Vallés-Torres J, Ramos S, López-Herrera D, De La Matta M, Gokhan S, Kucur E, Mugarra A, Soro M, García L, Sastre JA, Aguirre P, Salazar CJ, Ramos MC, Morocho DR, Trespalacios R, Ezequiel-Fernández F, Lamanna A, Pia Cantatore L, Laforgia D, Bellas S, López C, Navarro-Ripoll R, Martínez S, Vallverdú J, Jacas A, Yepes-Temiño MJ, Belda FJ, Tusman G, Suárez-Sipmann F, Villar J; iPROVE-OLV Research Network Group. Individualised, perioperative open-lung ventilation strategy during one-lung ventilation (iPROVE-OLV): a multicentre, randomised, controlled clinical trial. Lancet Respir Med. 2024 Mar;12(3):195-206.

doi: 10.1016/S2213-2600(23)00346-6. Epub 2023 Dec 5. PMID: 38065200.

https://pubmed.ncbi.nlm.nih.gov/38065200

1. Xiang Li, He Liu, Jun Wang, Zhi-Lin Ni, Zhong-Xiao Liu, Jia-Li Jiao, Yuan Han, Jun-Li Cao; Individualized Positive End-expiratory Pressure on Postoperative Atelectasis in Patients with Obesity: A Randomized Controlled Clinical Trial. Anesthesiology 2023; 139:262–273

doi: https://doi.org/10.1097/ALN.0000000000004603

https://pubs.asahq.org/anesthesiology/article/139/3/262/138185/Individualized-Positive-End-expiratory-Pressure-on

1. Gattinoni, L., Tonetti, T., Cressoni, M. et al. Ventilator-related causes of lung injury: the mechanical power. Intensive Care Med 42, 1567–1575 (2016).

https://doi.org/10.1007/s00134-016-4505-2

https://link.springer.com/article/10.1007/S00134-016-4505-2

1. Tartler TM, Ahrens E, Munoz-Acuna R, Azizi BA, Chen G, Suleiman A, Wachtendorf LJ, Costa ELV, Talmor DS, Amato MBP, Baedorf-Kassis EN, Schaefer MS. High Mechanical Power and Driving Pressures are Associated With Postoperative Respiratory Failure Independent From Patients’ Respiratory System Mechanics. Crit Care Med. 2024 Jan 1;52(1):68-79.

doi: 10.1097/CCM.0000000000006038. Epub 2023 Sep 11. PMID: 37695139.

https://pubmed.ncbi.nlm.nih.gov/37695139

1. Jeong H, Tanatporn P, Ahn HJ, Yang M, Kim JA, Yeo H, Kim W. Pressure Support versus Spontaneous Ventilation during Anesthetic Emergence-Effect on Postoperative Atelectasis: A Randomized Controlled Trial. Anesthesiology. 2021 Dec 1;135(6):1004-1014.

doi: 10.1097/ALN.0000000000003997. PMID: 34610099.

https://pubmed.ncbi.nlm.nih.gov/34610099

1. Chanques G, Conseil M, Roger C, Constantin JM, Prades A, Carr J, Muller L, Jung B, Belafia F, Cissé M, Delay JM, de Jong A, Lefrant JY, Futier E, Mercier G, Molinari N, Jaber S; SOS-Ventilation study investigators. Immediate interruption of sedation compared with usual sedation care in critically ill postoperative patients (SOS-Ventilation): a randomised, parallel-group clinical trial. Lancet Respir Med. 2017 Oct;5(10):795-805.

 doi: 10.1016/S2213-2600(17)30304-1. Epub 2017 Sep 18. PMID: 28935558.

https://pubmed.ncbi.nlm.nih.gov/28935558

•  De Jong A, Bignon A, Stephan F, Godet T, Constantin JM, Asehnoune K, Sylvestre A, Sautillet J, Blondonnet R, Ferrandière M, Seguin P, Lasocki S, Rollé A, Fayolle PM, Muller L, Pardo E, Terzi N, Ramin S, Jung B, Abback PS, Guerci P, Sarton B, Rozé H, Dupuis C, Cousson J, Faucher M, Lemiale V, Cholley B, Chanques G, Belafia F, Huguet H, Futier E, Azoulay E, Molinari N, Jaber S; EXTUB-OBESE trial group. Effect of non-invasive ventilation after extubation in critically ill patients with obesity in France: a multicentre, unblinded, pragmatic randomised clinical trial. Lancet Respir Med. 2023 Jun;11(6):530-539.

doi: 10.1016/S2213-2600(22)00529-X. Epub 2023 Jan 21. PMID: 36693403.

https://pubmed.ncbi.nlm.nih.gov/36693403

• Jaber S, Lescot T, Futier E, Paugam-Burtz C, Seguin P, Ferrandiere M, Lasocki S, Mimoz O, Hengy B, Sannini A, Pottecher J, Abback PS, Riu B, Belafia F, Constantin JM, Masseret E, Beaussier M, Verzilli D, De Jong A, Chanques G, Brochard L, Molinari N; NIVAS Study Group. Effect of Noninvasive Ventilation on Tracheal Reintubation Among Patients With Hypoxemic Respiratory Failure Following Abdominal Surgery: A Randomized Clinical Trial. JAMA. 2016 Apr 5;315(13):1345-53.

doi: 10.1001/jama.2016.2706. PMID: 26975890.

https://jamanetwork.com/journals/jama/fullarticle/2503470

• Carrillo A, Gonzalez-Diaz G, Ferrer M, Martinez-Quintana ME, Lopez-Martinez A, Llamas N, Alcazar M, Torres A. Non-invasive ventilation in community-acquired pneumonia and severe acute respiratory failure. Intensive Care Med. 2012 Mar;38(3):458-66.

doi: 10.1007/s00134-012-2475-6. Epub 2012 Feb 9. PMID: 22318634.

https://link.springer.com/article/10.1007/s00134-012-2475-6

• Kang BJ, Koh Y, Lim CM, Huh JW, Baek S, Han M, Seo HS, Suh HJ, Seo GJ, Kim EY, Hong SB. Failure of high-flow nasal cannula therapy may delay intubation and increase mortality. Intensive Care Med. 2015 Apr;41(4):623-32.

doi: 10.1007/s00134-015-3693-5. Epub 2015 Feb 18. PMID: 25691263.

https://pubmed.ncbi.nlm.nih.gov/25691263

• Lee KG, Roca O, Casey JD, Semler MW, Roman-Sarita G, Yarnell CJ, Goligher EC. When to intubate in acute hypoxaemic respiratory failure? Options and opportunities for evidence-informed decision making in the intensive care unit. Lancet Respir Med. 2024 Aug;12(8):642-654.

doi: 10.1016/S2213-2600(24)00118-8. Epub 2024 May 24. Erratum in: Lancet Respir Med. 2024 Aug;12(8):51.

https://pubmed.ncbi.nlm.nih.gov/38801827

• Grieco DL, Maggiore SM, Roca O, Spinelli E, Patel BK, Thille AW, Barbas CSV, de Acilu MG, Cutuli SL, Bongiovanni F, Amato M, Frat JP, Mauri T, Kress JP, Mancebo J, Antonelli M. Non-invasive ventilatory support and high-flow nasal oxygen as first-line treatment of acute hypoxemic respiratory failure and ARDS. Intensive Care Med. 2021 Aug;47(8):851-866.

doi: 10.1007/s00134-021-06459-2. Epub 2021 Jul 7. PMID: 34232336; PMCID: PMC8261815.

https://pubmed.ncbi.nlm.nih.gov/34232336

• Capdevila M, Ramin S, Capdevila X. Regional anesthesia and analgesia after surgery in ICU. Curr Opin Crit Care. 2017 Oct;23(5):430-439.

doi: 10.1097/MCC.0000000000000440. PMID: 28820799.

https://pubmed.ncbi.nlm.nih.gov/28820799

• Jabaudon M, Chabanne R, Sossou A, Bertrand PM, Kauffmann S, Chartier C, Guérin R, Imhoff E, Zanre L, Brénas F, Bazin JE, Constantin JM. Epidural analgesia in the intensive care unit: An observational series of 121 patients. Anaesth Crit Care Pain Med. 2015 Aug;34(4):217-23.

doi: 10.1016/j.accpm.2014.12.002. Epub 2015 May 23. PMID: 26004880.

https://pubmed.ncbi.nlm.nih.gov/26004880

• Jabaudon M, Genevrier A, Jaber S, Windisch O, Bulyez S, Laterre PF, Escudier E, Sossou A, Guerci P, Bertrand PM, Danin PE, Bonnassieux M, Bühler L, Heidegger CP, Chabanne R, Godet T, Roszyk L, Sapin V, Futier E, Pereira B, Constantin JM; EPIPAN study group. Thoracic epidural analgesia in intensive care unit patients with acute pancreatitis: the EPIPAN multicenter randomized controlled trial. Crit Care. 2023 May 31;27(1):213.

doi: 10.1186/s13054-023-04502-w. PMID: 37259157; PMCID: PMC10230742.

https://pubmed.ncbi.nlm.nih.gov/37259157

• Jabaudon M, Zhai R, Blondonnet R, Bonda WLM. Inhaled sedation in the intensive care unit. Anaesth Crit Care Pain Med. 2022 Oct;41(5):101133.

doi: 10.1016/j.accpm.2022.101133. Epub 2022 Jul 27. PMID: 35907598.

https://pubmed.ncbi.nlm.nih.gov/35907598

Elie Azoulay

• Maslove, D.M., Tang, B., Shankar-Hari, M. et al. Redefining critical illness. Nat Med 28, 1141–1148 (2022).

https://doi.org/10.1038/s41591-022-01843-x

https://www.nature.com/articles/s41591-022-01843-x

• Girard TD, Exline MC, Carson SS, Hough CL, Rock P, Gong MN, Douglas IS, Malhotra A, Owens RL, Feinstein DJ, Khan B, Pisani MA, Hyzy RC, Schmidt GA, Schweickert WD, Hite RD, Bowton DL, Masica AL, Thompson JL, Chandrasekhar R, Pun BT, Strength C, Boehm LM, Jackson JC, Pandharipande PP, Brummel NE, Hughes CG, Patel MB, Stollings JL, Bernard GR, Dittus RS, Ely EW; MIND-USA Investigators. Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness. N Engl J Med. 2018 Dec 27;379(26):2506-2516.

doi: 10.1056/NEJMoa1808217. Epub 2018 Oct 22. PMID: 30346242; PMCID: PMC6364999.

https://pubmed.ncbi.nlm.nih.gov/30346242

• Mart MF, Boehm LM, Kiehl AL, Gong MN, Malhotra A, Owens RL, Khan BA, Pisani MA, Schmidt GA, Hite RD, Exline MC, Carson SS, Hough CL, Rock P, Douglas IS, Feinstein DJ, Hyzy RC, Schweickert WD, Bowton DL, Masica A, Orun OM, Raman R, Pun BT, Strength C, Rolfsen ML, Pandharipande PP, Brummel NE, Hughes CG, Patel MB, Stollings JL, Ely EW, Jackson JC, Girard TD. Long-term outcomes after treatment of delirium during critical illness with antipsychotics (MIND-USA): a randomised, placebo-controlled, phase 3 trial. Lancet Respir Med. 2024 Aug;12(8):599-607.

doi: 10.1016/S2213-2600(24)00077-8. Epub 2024 Apr 30. PMID: 38701817; PMCID: PMC11296889.

https://pubmed.ncbi.nlm.nih.gov/38701817

• Andersen-Ranberg NC, Poulsen LM, Perner A, Wetterslev J, Estrup S, Hästbacka J, Morgan M, Citerio G, Caballero J, Lange T, Kjær MN, Ebdrup BH, Engstrøm J, Olsen MH, Oxenbøll Collet M, Mortensen CB, Weber SO, Andreasen AS, Bestle MH, Uslu B, Scharling Pedersen H, Gramstrup Nielsen L, Toft Boesen HC, Jensen JV, Nebrich L, La Cour K, Laigaard J, Haurum C, Olesen MW, Overgaard-Steensen C, Westergaard B, Brand B, Kingo Vesterlund G, Thornberg Kyhnauv P, Mikkelsen VS, Hyttel-Sørensen S, de Haas I, Aagaard SR, Nielsen LO, Eriksen AS, Rasmussen BS, Brix H, Hildebrandt T, Schønemann-Lund M, Fjeldsøe-Nielsen H, Kuivalainen AM, Mathiesen O; AID-ICU Trial Group. Haloperidol for the Treatment of Delirium in ICU Patients. N Engl J Med. 2022 Dec 29;387(26):2425-2435.

doi: 10.1056/NEJMoa2211868. Epub 2022 Oct 26. PMID: 36286254. https://www.nejm.org/doi/full/10.1056/NEJMoa2211868

• Cao L, Chen Q, Xiang YY, Xiao C, Tan YT, Li H. Effects of Oxygenation Targets on Mortality in Critically Ill Patients in Intensive Care Units: A Systematic Review and Meta-Analysis. Anesth Analg. 2024 Oct 1;139(4):734-742.

doi: 10.1213/ANE.0000000000006859. Epub 2024 Sep 4. PMID: 38315626.

https://pubmed.ncbi.nlm.nih.gov/38315626

• Nielsen FM, Klitgaard TL, Siegemund M, Laake JH, Thormar KM, Cole JM, Aagaard SR, Bunzel AG, Vestergaard SR, Langhoff PK, Pedersen CH, Hejlesen JØ, Abdelhamid S, Dietz A, Gebhard CE, Zellweger N, Hollinger A, Poulsen LM, Weihe S, Andersen-Ranberg NC, Pedersen UG, Mathiesen O, Andreasen AS, Brix H, Thomsen JJ, Petersen CH, Bestle MH, Wichmann S, Lund MS, Mortensen KM, Brand BA, Haase N, Iversen SA, Marcussen KV, Brøchner AC, Borup M, Grøfte T, Hildebrandt T, Kjær MN, Engstrøm J, Lange T, Perner A, Schjørring OL, Rasmussen BS; HOT-COVID Trial Group. Lower vs Higher Oxygenation Target and Days Alive Without Life Support in COVID-19: The HOT-COVID Randomized Clinical Trial. JAMA. 2024 Apr 9;331(14):1185-1194.

doi: 10.1001/jama.2024.2934. Erratum in: JAMA. 2024 May 28;331(20):1771MID: 38501214; PMCID: PMC10951852.

https://pubmed.ncbi.nlm.nih.gov/38501214

• Buell KG, Spicer AB, Casey JD, Seitz KP, Qian ET, Graham Linck EJ, Self WH, Rice TW, Sinha P, Young PJ, Semler MW, Churpek MM. Individualized Treatment Effects of Oxygen Targets in Mechanically Ventilated Critically Ill Adults. JAMA. 2024 Apr 9;331(14):1195-1204.

doi: 10.1001/jama.2024.2933. PMID: 38501205; PMCID: PMC10951851.

https://jamanetwork.com/journals/jama/article-abstract/2816677

Studii clinice:

1. https://ctv.veeva.com/study/effects-of-high-flow-oxygen-therapy-and-non-invasive-ventilation-on-lung-volumes-and-on-upper-airway

https://clinicaltrials.gov/study/NCT05812911?cond=Respiratory%20Failure&term=kiss&rank=1